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Search Results for " complement factor d "

Targets Recommended: Complement System

9

抑制剂 & 化合物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T38332	Complement factor D-IN-2	Complement System	Immunology/Inflammation
	Complement factor D-IN-2 是 omplement factor D 的有效抑制剂，在替代补体途径的早期和关键时刻靶向 factor D 并抑制补体级联反应。Complement factor D-IN-2在自身免疫疾病的方面有研究的价值。
T16898	Complement factor D-IN-1	Others	Others
	Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively).
T8509	Danicopan ACH-4471	Complement System	Immunology/Inflammation
	Danicopan (ACH-4471) 是一种可口服的小分子 D 因子选择性抑制剂，对人 D 因子具有高结合亲和力，Kd 值为 0.54 nM。它可抑制补体替代途径 (APC) 的活性，具有阻断阵发性夜间血红蛋白尿 (PNH) 和非典型溶血性尿毒症综合征 (aHUS) 的补体替代途径的潜力。
T39493	Vemircopan ACH0145228,ACH-5228,ALXN2050
	Vemircopan is a complement factor D inhibitor.
T76814	Lampalizumab
	Lampalizumab (RG 7417) 为靶向补体通路中补体因子 D (Factor D) 的人源单克隆抗体。通过结合外位点，该药物立体阻断因子 B 进入活性位点，用于老年性黄斑变性 (AMD) 研究。
T11269	FD-IN-1	Others	Others
	FD-IN-1 is a factor D (FD) inhibitor with an IC50 of 12 nM.FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5μM, respectively. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system.
T38803	Factor D inhibitor 6
	Factor D inhibitor 6 is a potent, highly selective, orally active compound that specifically inhibits the activity of factor D (FD). It demonstrates an IC50 of 30 nM and a Kd of 6 nM. Notably, Factor D inhibitor 6 does not exhibit any inhibitory effects against factor B, classical and lectin complement-pathway activation, nor does it interfere with a broad array of receptors, ion channels, kinases, and proteases.
T62020	Pelecopan
	Pelecopan (BCX9930) 是有效的、选择性的口服补体因子D 抑制剂 (IC50= 14.3 nM)。Pelecopan 可以预防PNH 中的血管内和血管外溶血。
T77219	N-((Allyloxy)carbonyl)-N-methyl-L-alanine
	N-((Allyloxy)carbonyl)-N-methyl-L-alanine 是一种丙氨酸衍生物。N-((Allyloxy)carbonyl)-N-methyl-L-alanine 可用于合成补体因子 D (complementfactor D) 抑制剂。补体因子 D 抑制剂可用于免疫系统相关疾病的研究。

化合物

Complement factor D-IN-2

Cat.No: T38332

Target: Complement System

Complement factor D-IN-1

Cat.No: T16898

Target: Others

Cat.No: T8509

Synonym: ACH-4471

Target: Complement System

Cat.No: T39493

Synonym: ACH0145228,ACH-5228,ALXN2050

Cat.No: T76814

Cat.No: T11269

Target: Others

Factor D inhibitor 6

Cat.No: T38803

Cat.No: T62020

N-((Allyloxy)carbonyl)-N-methyl-L-alanine

Cat.No: T77219

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02183	Complement Factor D/CFD Protein, Human, Recombinant (His) PFD,DF,complement factor...	Human	HEK293 Cells
	Complement Factor D/CFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.8 kDa and the accession number is P00746.
TMPJ-00149	Complement Factor D/CFD Protein, Mouse, Recombinant (His) C3 convertase activator,28 kDa adipocyte p...	Mouse	HEK293 Cells
	Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3, which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the...
TMPH-03272	Complement factor D Protein, Rat, Recombinant (His) Adipsin,Df,Adn,C3 convertase acti...	Rat	P. pastoris (Yeast)
	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
TMPY-02167	Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293) DF,Adn,complement factor...	Mouse	HEK293 Cells
	Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.4 kDa and the accession number is P03953-2.
TMPK-00755	Complement Factor D/CFD Protein, Human, Recombinant (hFc) C3 convertase activator,DF,AMBP-1,EC 3.4.21,EC 3.4....	Human	HEK293 Cells
	Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Human, Recom...
TMPK-00151	Complement Factor D/CFD Protein, Mouse, Recombinant (hFc) C3 convertase activator,AMBP-1,PFD,FACTOR ...	Mouse	HEK293 Cells
	Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Mouse, Recom...
TMPK-00671	Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His) Adipsin,CFD,ADN,Complement	Rhesus	HEK293 Cells
	Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Rhesus macaq...
TMPH-03271	Complement factor D Protein, Rat, Recombinant (His & Myc) Adn,C3 convertase activator,Properdin ...	Rat	HEK293 Cells
	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D Protein, Rat, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 29.8 kDa and the accession number is P32038.
TMPH-02607	Complement factor B Protein, Mouse, Recombinant (His) C3/C5 convertase,Complement factor B,Cfb,B...	Mouse	E. coli
	Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase.
TMPH-03038	Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO) Cobra venom factor,Complement C3 homolog,C...	Naja kaouthia	E. coli
	Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely re...

重组蛋白

Complement Factor D/CFD Protein, Human, Recombinant (His)

Cat.No: TMPY-02183

Species: Human

Expression System: HEK293 Cells

Complement Factor D/CFD Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00149

Species: Mouse

Expression System: HEK293 Cells

Complement factor D Protein, Rat, Recombinant (His)

Cat.No: TMPH-03272

Species: Rat

Expression System: P. pastoris (Yeast)

Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293)

Cat.No: TMPY-02167

Species: Mouse

Expression System: HEK293 Cells

Complement Factor D/CFD Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00755

Species: Human

Expression System: HEK293 Cells

Complement Factor D/CFD Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00151

Species: Mouse

Expression System: HEK293 Cells

Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00671

Species: Rhesus

Expression System: HEK293 Cells

Complement factor D Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03271

Species: Rat

Expression System: HEK293 Cells

Complement factor B Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02607

Species: Mouse

Expression System: E. coli

Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)

Cat.No: TMPH-03038

Species: Naja kaouthia

Expression System: E. coli

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